GLUCOVANCE 500/2.5 30tab

 Glucovance 500 mg / 2.5 mg Tablets Active Ingredients: Metformin Hydrochloride 500 mg, Glibenclamide 2.5 mg Pack Size: 30 Tablets Therapeutic Class: Oral Antidiabetic – Biguanide + Sulfonylurea CombinationDescription: Glucovance combines two antidiabetic agents: metformin (a biguanide) and glibenclamide (a sulfonylurea), used to manage blood glucose in patients with type 2 diabetes mellitus. Metformin decreases hepatic glucose production and enhances insulin sensitivity, while glibenclamide stimulates insulin secretion from the pancreas.Indications: For the treatment of type 2 diabetes mellitus in adults when diet, exercise, and monotherapy with either metformin or glibenclamide do not provide adequate glycemic control. Dosage and Administration: Starting dose: Usually one tablet once or twice daily with meals to reduce gastrointestinal side effects. Dosage should be individualized based on blood glucose response. Do not exceed the maximum recommended daily dose (usually 2000 mg metformin / 20 mg glibenclamide). Tablets should be swallowed whole with water. Contraindications: Type 1 diabetes mellitus Diabetic ketoacidosis Moderate to severe renal or hepatic impairment Known hypersensitivity to sulfonylureas, metformin, or any tablet component Pregnancy and lactation Warnings and Precautions: Risk of lactic acidosis from metformin, especially with impaired renal function Risk of hypoglycemia, particularly in elderly or those with irregular meals Monitor blood glucose and renal function regularly Use caution with alcohol intake Possible Side Effects: Hypoglycemia Nausea, vomiting, or diarrhea Headache Weight gain Allergic skin reactions Storage: Store below 25°C in a dry place, away from moisture and direct light.