JANUMET XR TABLETS 100/1000MG 28TAB

 Janumet XR 100/1000 mg Prolonged-Release Tablets Active Ingredients: Sitagliptin 100 mg, Metformin Hydrochloride 1000 mg Pack Size: 28 Tablets Therapeutic Class: Oral Antidiabetic – DPP-4 Inhibitor + BiguanideDescription: Janumet XR is a combination of sitagliptin (a DPP-4 inhibitor) and metformin (a biguanide) designed to help manage blood glucose levels in adults with type 2 diabetes mellitus. Sitagliptin enhances incretin levels to increase insulin release and decrease glucagon secretion. Metformin lowers hepatic glucose production and improves insulin sensitivity.Indications: For adults with type 2 diabetes mellitus to improve glycemic control when diet and exercise are not sufficient. Can be used as monotherapy or in combination with other antidiabetic agents. Dosage and Administration: Recommended dose: One tablet once daily with the evening meal. Dosage should be individualized based on the patient’s current regimen and renal function. Tablets must be swallowed whole; do not split, crush, or chew. Maximum daily dose: sitagliptin 100 mg and metformin 2000 mg. Contraindications: Type 1 diabetes mellitus Diabetic ketoacidosis Moderate to severe renal impairment Known hypersensitivity to sitagliptin, metformin, or tablet components Warnings and Precautions: Monitor renal function before and during treatment Risk of lactic acidosis associated with metformin Not recommended in pregnancy or during breastfeeding Use with caution in hepatic impairment or alcohol abuse Possible Side Effects: Nausea Diarrhea Headache Upper respiratory tract infections Hypoglycemia (especially when used with insulin or sulfonylureas) Storage: Store below 30°C in a dry place, away from moisture and light.