JANUMET XR TABLETS 50/500MG 56TAB

 Janumet XR 50/500 mg Prolonged-Release Tablets Active Ingredients: Sitagliptin 50 mg, Metformin Hydrochloride 500 mg Pack Size: 56 Tablets Therapeutic Class: Oral Antidiabetic – DPP-4 Inhibitor + BiguanideDescription: Janumet XR combines two oral antihyperglycemic agents: sitagliptin, a DPP-4 inhibitor, and metformin, a biguanide. Sitagliptin improves glycemic control by enhancing the effects of incretin hormones, promoting insulin release, and reducing glucagon levels. Metformin works by decreasing hepatic glucose production and improving insulin sensitivity.Indications: For adults with type 2 diabetes mellitus to improve blood glucose control when diet and exercise alone are inadequate. Suitable as monotherapy or in combination with other antidiabetic agents. Dosage and Administration: Usual starting dose: one tablet once daily with the evening meal. Dosage should be individualized according to the patient’s clinical profile and kidney function. Do not crush, split, or chew the tablets. Maximum daily dose: sitagliptin 100 mg and metformin 2000 mg. Contraindications: Type 1 diabetes mellitus Diabetic ketoacidosis Moderate to severe renal impairment Known hypersensitivity to sitagliptin, metformin, or tablet components Warnings and Precautions: Monitor kidney function regularly Risk of lactic acidosis, particularly in renal impairment Not recommended during pregnancy or breastfeeding Caution with alcohol intake and liver disease Possible Side Effects: Nausea Diarrhea Headache Hypoglycemia (especially with insulin or sulfonylureas) Respiratory infections Storage: Store below 30°C in a dry place, away from light and moisture.